Endocrine Abstracts

Background: Bariatric surgery (BS) results in metabolic pathway recalibration. When major metabolic change occurs, blood protein components have a key role and can be altered significantly. We set out to identify potential biomarkers of change in plasma following BS in people achieving remission of type 2 diabetes mellitus (T2DM).Methods: Longitudinal analysis was performed on serum samples from 10 individuals who all achieved remission of T2DM following...

Background: Bariatric surgery (BS) can have significant effects on multiple body systems and has been an effective intervention for morbid obesity, improving many comorbid medical conditions that are associated with mental health and cognitive dysfunction. It was previously shown that cognitive impairment was partly reversible in obese patients after BS [1], however, the effects of BS on proteins associated to central nervous system (CNS) still unknown. We evaluated if there a...

Aims: We used sequential window acquisition of all theoretical fragment ion spectra Mass Spectrometry (SWATH-MS) to identify proteins acting as markers of remission of type 2 diabetes (T2DM) in patients who lost weight after bariatric surgery.Background: Bariatric surgery results in remission of T2DM in up to 80% of patients. The mechanisms underpinning are largely unknown. N-acetylmuramoyl-L-alanine amidase (PGLRYP2) is an immune response enzyme that br...